                       ˿µϣ20040801գ

04.08.01, ӡʳƷȫĿֻš
04.08.01, coyotejoyаӦͣ(Thalidomide)Ĺ¡
04.08.01, Ԫ¡˲ħ
04.08.01, ־ڵªо
04.08.01, ơʧ֪Ǹʵ»㡷
04.08.01, ҲƶȲ۸ʵ»Ӧ¼ȡ
04.08.01, ϵۿ𣿡
04.08.01, ܡɳ磺ǹĴ𣿡
04.08.01, 20ӣǶ˸ǻ֮䡷
04.08.01, ڻӶʵ״౨
04.08.01, ɫվɴץһǧܷŹһ
04.08.01, 衶googleйԶʹ
04.08.01, ˴б

˿(www.xys.org)(xys.dxiong.com)(xys.3322.org)(xys.freedns.us)

                       ʳƷȫĿֻ

                            ӡ

    ⼸괨ˡˮ㡱ھΪУˮ㡱öѿ
Զġڽ4·ڱȥһҳȥĴ˹¹ӣڵ
ˡˮ㡱֮󣬷Աȴʣʲôףײˡˡ
˻Ƕѿɴ棬ԱԻЩ˲ҳԶѿˡ
̨ġÿ桱ոս¶дһ
Ҷѿøֻѧԭϴ߳ѿûԭϡշۡݣȻ
еһЩС͹ݡʳá

    йʳƷȫѾãʮǰһڹڶʱ
ѳõеηę́šֱһʱ䣬ű
̨н¶Ӥ̷ۡˮƵڷ˿е
ηݵĽ𻪻ȡ̫ɡӹҵɽϳ
ס֡ݵˮʳƷҵƵĴݲˡɫ
ĺļ²ˡ㳦衢ӡ񡢽͡ӡ
ƤƻˡճʳƷȫܺжʡֻҪйһ
ʱ䣬ԽжʳƷĻἸûСʹں⣬Ҳ޷ȫ⡣
ʳƷҩƷ79ոո߷棺Ҫй
Ӥ̷ιӤΪйӤ̷۵İȫԺӪֵû
бϡþŦԼ۵һ֡԰
йӤ̷ۣ䵰ʺͱ׼߷֮һ֬
ֻķ֮һƺþĺ͡

    ״ȷֵȫ绪˵Ĺעϵÿʳ
йʳƷĺѵĽɴķŭͿֻҲͿ⡣
ڿֻ֮Уȴ˷ѧĹ롣Ҳֹһεؼ
׫йʳƷȫʱתʳƷҲΪһΣ˽ȥ
棺ûܹȷ֤һȱʳƷƼ񻰵ת
ʳƷǲִġ˶ħСʳƷֲ
塱֮ǡءܿ2004630գȥʳ
ƷҪֲöࡣŵľˣת򡱾
ʲôҲȻֻҪ֪ʲôǡת򡱣Ϳȷ֤ת
ʳƷʲô˶ħСǰѷָģĿǰ
κ֤ݱתʳƷͬתʳƷк
֤ݱеתʳƷ޺洦
ʳӪֵ򽵵ԭʳекɷ֣˶Դ
ţҪ֪״ٴ棺ҪסDDTԼʬĥ
ţϵΣպҲڶԺŽġͬģΪ
ʷйһЩڶԺ֪ӣΪΪ
ȫĶδضǰȫĻôͬһ׼ҲӦڽ챻
ΪǰȫʳƷתʳƷĻǻʲô
ΪһʳƷǾ԰ȫģʹǱȫʳ˼
ǧʳƷҲδؾͰȫơըʳƷ
ʳãֱʮŷֺ°ɶԡ

    еִѧˣ˵ִѧܡ
ǵĽһʳܲܳԻԣֽͱֽҪܣ
̨͵̨ҪܣרҺרҲҪܣǶޱȷĵ
ͳͳǡִѧʵ֤ʱ԰пԺʳƷ
ҩƷֵıϡߵýĿѧѧҪ
ѧȻſ϶飬ʱҲЧǻѧ
ˣû˿ѧҲû˸ĽɡԳʲô⣬˱
򵥵öࣺζͣ˵㣻ǳʲôʵ˭Ҳ֪
Įʲô˭˵㣿ءܿ2004630գſѧ
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̣Ǹʱǡ顱ģΪѧϾǻ֪ʶ
ɿķʳƷȫ棬ĳЩǰרǻ飬
רҵһµġȻ˴ſѧٻ
ĲڴΪĳЩϿѧ绹Ͳſѧ
ʵҭʳǹӴƹˤӹѧ
˵㡱ôǻǦޱı׻岻
ǻᵼǦжҲšһ֧̣ʤɡ
ҲкҲ֪Ŀǰʳ
ƷԽʲôΪǶִѧǵģ
ǵġ

    7³ٴεͬһҴ˹ݳԡˮ㡱ʱԱѲ
ʲôף뵱Ȼ϶ѿˡ֪ΪҶڱҷ
֮󱱾ĶѿûأΪֲ֣ľˡ
޴ڵʳƷİΧУνʳƷ
ȫ⣬ֻһѧ⡣

2004.7.15.

򡷰¿2004.15

(XYS20040801)

˿(www.xys.org)(xys.dxiong.com)(xys.3322.org)(xys.freedns.us)

аӦͣ(Thalidomide)Ĺ

coyotejoy
 
Ӧͣ(Thalidomide)ҩʷһа֡ҩ
һҵ¹˾Chemie Grunenthal1953ϳɣ1957꿪ʼΪһ
º͵ֹ¼ɸù˾Ĵڵ¹Ӣŷ޹Һͼô
ۡʱеĸŮڼ糿ͷκŻµë
Ȼҩв꼴֣ܶиֻҪڻкͷڷùһƬ
ҩС֫ȫɴûлֻк̵ܶĺ󺣱
һһءΪȱĺ֢֫(phocomelia)
Ȼ֢֫һֺĵļоʱŷ޵ָ߱
ֵӤȱȫҩӦͣ 𣬶ڵͷӤ
֫γڡӦͣһЩλȱʧ۾ȱݣ
򳦵Ļ䣬ϵͳëȵȡԼ46ҵһ
ӤЩαҵسмǧӤΪҩĶδ
µҩ196111±ǿдŷгأ19623´Ӽô
гء

ӦͣǶսʮгֵ򾲼еһʱΪ
սоͿľ˳ҩɿأ
ϴҩûκοصԣְ򾲴߼Ҵ
޶ûиãиҲȫȫĹܾͱȰͱ򾲼
ҵˡȻЩĴ׼ȷ֮ǰѾһЩѧʵ֤
кãǸ¹˾ûһʵ飬
ʵҲܲϽɿ֧ܶʵԱ˾Ĵ
νĲ˷ҩƵļ֤ʱŷ޹ҵҩڿߺܲƣ
ܶҩûֲԾг򿪴ڹֱ̨ӳۡ

1960꣬һСҩ˾Richardson-MerrellFDA뽫
ӦͣƷKevodonСʱյʳƷҩ(Food 
and Drug AdministrationFDA)ְĸ˹˶(Frances KelseyMD
PhD) ʿ룬еһЩҩݲ⣬Ҷ
뱨ᵽĸҩ׸úܾ裬ҲһЩ
Լ˵ҩĲɿּҪ뷽ṩĿѧ
ǲǵļ֤ҩ˾ֺ֮УӦͣ
Ӥε֢״Ѿŷ޺ͼô󸡳棬FDAȻϾܾ
ҩΪһŮˣOhNOһŮѧҵġ̡ӹһ١
Ϊˣ˹ٻ˿ͳ䷢Ľ¡FDAûн
λϵͳҲƣ˱ҩ˾˵Ĺż
⵽Щͨʩӵѹû׼Ӧͣг
FDA˽ٰϵһҪҵFDAӰ١
ҲFDAչʷϵһҪ̱½ͨüǰʱѩص
FDAȨҪķ֮һʳƷҩ﷨ҩĿ
-˹(Kefauver-Harris Amendments)1962ͨҪҩﱻ
׼ͨǰ뾭ϸļԱ֤䰲ȫЧ涨ṩ
ҩĲӦгڶ԰(°»ͻ)ϣҩΪ
Ҳ涨FDA׼ϸµ롰Ӧͣ صо
Ӧͣоȣδֹͣ

ӦͣĻԳɷһСӻ̪ͪ
(Alpha-(N-phthalimido)glutarimide)ǹȰһ
R(+)S(-)ֶӳ칹塣νӳ칹壬ǵĻѧͬ
άṹɾԳƣ·һøֻѡԵһ
巴ӦԡӦͣԣR(+)ֹʹЧS(-)̥
ΡøЧҺɫ(HPLC)ëϸܵӾ(CE)ȼֶοԲֺӳ
칹ǣӦֶͣӳ칹Ѹ
໥תʹκһ칹壬ڣĵСʱҲѸת
ɵĶӳ

оֶԡӦͣںıֺܲһл
ʵʱһЧĶģͼ⵽̥»á֣ͬ
ͬеĲͬԡӦͣŲͬĴлٴǰ
ҩܵĶԣȻҩеû»ԡ
ӲӴκϿĲһ鳤ද޺ķ
ƣǵӴоΪʲôӦͣЩΡȻ
Գɱ̫ߣڸ

о̥³´л˵ķǳͬһЩѧƷӰٵķ
ȴƻóٵĹܡԡӦͣ ¼֮ҩ˾ڽҩ
ʱرעǷҩиӰ졣кüֳҩ
̥ΡһֿҩҶᣬҩ˫ͪͶ壬
Ѫͪ㶹صȡڣڡӦ̥ͣεĻ
ֻһЩ˵ѡЩ˵ʮγɵ˵
˵ʮγɵѪ(angiogenesis)˵ѹ˵

ܡӦ̥ͣԵ»ãȻ1964ɫдŸ
л˹(Jacob Sheskin)Ӧͣ Ϊ򾲼һλԺ
(erythema nodosum leprosum, ENL) 粡ˣطʹENL
֢״ܿõ˼ʵ鱻оӦͣ ENLá
1991꣬˷մѧ粡רҼ(Gilla Kaplan)о
ӦͣENLĿЧΪƲڵһߵװ
(alpha tumor necrosis factor-TNF) ĺϳɣ
ˮƽ-TNFһϸӻ˵ѧʹڸȾвİѪ
ţԿֵ塣ܴ̼ϵͳںܶĶԼУȻ
-TNFĹȲ²˲һ񻯡Ӧͣ Ԧ-TNF
ʹܳΪһߵںͿҩ(Immunomodulatory Drugs
IMiDsanti-inflammatory drug)

ί˫äٴʵ飬173ԵĲ92%˵֢״
ˡ֯(World Health OrganizationWHO)쵼һģ
4552ENL˲ٴоУ99%Ĳ˵Ĳõ˸ơ
ˣӦͣ һżЧõҩǴҶҩ
൱ú34꣬1998716գһ
˾CelgeneFDA׼ӦͣENLĹС
緶ΧڵһеĹҡǣҩȥϸ
ڿ֮£ҩɴ򿪴ܻãҩĴעǼǣ
ÿһԼõĲֵַ¼Ҵ
˹µ»áһΪSTEPS(A System for 
Thalidomide Education and Prescribing Safety) ĵغͽFDA
CelgeneͬƶִСCelgene˾⽫ҩΪThalomidǳ
ƣԾǹĹȥ

-TNFĹȲENLĲأҲϵͳĲ
أؽףνˣŧֲ￹(chronic 
graft-vs-host disease, CGVHD)ĤƤҵȡڰ̲
УҲйTNFǿHIVĸƣٰ̲Ŀɢ
ӦͣƦ-TNFĹȲֹźţͬʱҲѹHIV
ɢİ̲ٴоС(AIDS Clinical Trials GroupACTG)
Ķ෽о֤ˡӦͣ԰̲˵˥ͿǻЧá
Celgene˾ҲƵٴʵоһáӦͣ HIV
صʵڵڶڽ׶Ρ1995꣬FDA׼£Celgeneһ
˥İ̲ṩӦͣҵƻ

Ӧͣ ̥ĿٷϸԤʾܿʧȥƷ
İ֢ϸͬʱ֢ĽһҲ-TNFˮƽء
תƵĹУдĶϸСѪܵ
(angiogenesis) ЩСѪܱܵİϸѪҺӪ
ûЩڡ ĹܵϸԷή1994꣬ѧ
̴(Judah Folkman) о֡Ӧͣ пѪ
(anti-angiogenesis)ʡʵӦͣ ȷʵѪƤ
(Vascular Endothelial Growth FactorVEGF) ͼԳάϸ
(basic Fibroblast Growth FactorbFGF)ӶѪܵɣ
ôֱ˵·ֵġӦͣ ֿѪ
ѧ̽оԸְ֢2000124еĵ42
ѪҺѧȻϣ(Mayo Clinic in Rochester Minn.)
S.ɭ?Ү(S. Vincent Rajkumer)ˡӦͣƶ෢
(Multiple Myeloma MM)ķǳǰĽ89ڻʧܵ
MMʹáӦ֮ͣһиƵ״ڹ״̬ķӦ10%
Ĳ˿ӽȫҮȽоˡӦͣԻʧܵ
MMߺϵMMߵáϵMMߣʹáӦͣ 
ʱصƤףȻMMߣӦͣ ֹ
ʹЩãҲѡ Ӧͣ ѪҲǽ
̥εļ˵֮һ߼ϵûȫ֤ʵ

ڡӦͣһҪʷ1998꣬иT-
ϸ(T-cell receptor, TCR)Tϸ(T-?ell co-stimulatory 
activityTCCA) ҪʹáӦͣ пܱ߸
ٽĳЩʧЧ߷ӦǿĳЩ֢˶԰ϸĵֿ


춡Ӧͣ ʣƦ-TNFѪɺ͸Tϸ
áӦͣ ܿƵ֢ǰٰѪϸ
ѳ鰩񾭽(ڰ̲г), 
Сϸΰ͸ϸ۲߶񻯡Ƶİֻ֢Ӱ
̥ĳЩ֯һϵԼ150ڡӦͣ 
ʵڽСٴʵƱϸƣμٴʵŮ־Ը
飬лле򶼱ԶЩʵ顣ʵ90%ġ
Ӧͣ ڰ֢ϡΪһϵ;һӯ
ҩˣ۶ÿԼڣȻ֮С

춡Ӧͣ ĻѧṹЧCelgeneҲоµ
ϣһĻܾҩŵ㣬ͬʱȥ˿־
»ԣĸҲСЩһĻﶼIMiDs
ѡԵϸҩ(Selective Cytokine Inhibitory DrugsSelCIDs) 
ԱȡӦͣ ǿܶ࣬ͬʱΪģ͵û̥
»ԵĻѾ֡20032£Ӧͣ һӴ
CC-5013һIMiDҩͨٴʵ飬FDA׼ΪƸMM
ѡҩ20034£ҩֱFDA׼һѪ
myelodysplastic syndromes(MDS) FDAĿǰû׼MDS
ҩһӴCC-4047MMǰٰĵڶٴʵ
С׻һЩҲͻһʽ׼С

ӦͣЩЧͻȻо֮СҩƼ
ЧͰȫȻȻϸûԶԡӦͣ 
ЧСĵ֤֮УӵûܻҪһܽ
ʾڣǶСӻĻѧѾ˽⣬Ľṹ
ӣȻǶ屾ĸӻԼּĳͷչ
ܲԶСӻ໥ڻȫԤ
ͰաԴˣѧǻβо֮Сҩֻһû
û־Сӻǲܵжа֪
ажȫ౾㣬ôʹʹ
ʩ˺˺ܻݡʵǵо
ܵĹñ춨ڿѧϵͳѧҽѧо֮ϡһҩĵ
ʹ漰һӴ磬Ӵ漰ͬɫˣ
ѧоԱҩ˾ߣߣԼʹߡ
ˡѬġ˶ԼͶͬĶ
ӦֻͣгǼҵ¹˾Chemie Grunenthal͵ͼ
дҩRichardson-Merrell˾ھӿĴѲ֪գ
ıٳԼִҩҵļܻڸҵĳֻһ
չ¹ҩȫ׼趨ز趼ϸϵͳͿѧ
ɽڲסϾȥӦͣ͵ıϲ·Ƿ
Ĵ棬ҲִҩҵԽ˸ķչ׶Ρ

ܡӦͣӰӤԼ5ǧԳ˸
౶ǿںšеһЩŽһ˳䵱ҩ˾
֮ܺһô󡰷Ӧͣ ܺЭܲ
(Randy Warren)˵ȵмЧͬʱûһظõ
ӦͣʱҲףӦͣɥ̡֮

References:

1. Nelms, S., et al Chemistry of Thalidomide
2. www.devbio.com Thalidomide as a TeratogenApril 11, 2003
3. www.fda.gov Giving Thalidomide a Second Chance, June, 1997
   www.fda.gov/cder/news/thalidomide.htm
4. Drug Watch: Thalidomides Long and Winding Road the Bulletin 
of Experimental Treatments for AIDS, April 1998, the San Francisco 
AIDS Foundation
5. Wright, K. Thalidomide is Back Discover, April, 2000
6. Perri III, A. et al.A Review of Thalidomides History and 
Current Dermatological ApplicationsDermatology Online Journal, Vol. 9, 
No. 3, 2003
7. Lewis, R. The Return of ThalidomideOnce-feared drug finds new 
applications The Scientist 15[2]:1, Jan. 22, 2001
8. www.xys.org ӱӡʶҩ֮ţķǴҩͱƷг
9. BBC News: Thalidomide: 40 years on 7 June, 2002
10. www.celgene.com/thalomid/
11. www.biologictherapy.org/aboutbiotherapy/about_thalidomide.html
12. Hilts, P. Protecting Americas HealthThe FDA, Business, and 
One Hundred Years of Regulation Alfred A. Knopf New York, 2003
13. Hutchins, A. The Future of Thalidomide2002
14. Beale, B. Thalidomide Returns to RespectabilityABC Science 
online 12/09/2003
15. Stephens, T.Reinventing Thalidomide Chemibytes e-zine 2001
16. Bartlett, J. B. et al The evolution of Thalidomide and its IMiD 
derivatives as Anticancer Agents Nature Reviews Cancer, Vol. 4, 2004, 
314-322

(XYS20040801)

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    ĳЩεĿѧҡӰ죬ƣ
ѧ֪ܶΥŴѧʶġѧԣɱιڵƭ
֡

ĵɾڰ桶Ӧħ¡ڱƼ2004.7.21,δ
ɾڵԭģ

(XYS20040801)

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ڵªо

־

Ҫ˵ǣǡ¼Ǹʵ»һλֿѡ
Ŀǰ֪ƪӳ֮ǰʵ»κûκվ
ý϶һ¼κεĹۣǼ֧ܵ
ȡһкжͬʱҲ˿ܵĸӰ
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ʱ䣬Ϊʵ»ѣһֱйע¼ķչΪ
ֹǵԤϣ

1	һ¼ڹ⻪ѧľ޴죻

2	һڴĿãƱ
֮µĳªо

ڵһ㣬ܶҲᵽ֮ԳԤϣ
ضԡҪ˵ǵڶ㡣

ֳĳªо

ªоһһҡ

Ӧʵ»ҵı󿼲еġ˵жԺĹ̸
˽Ϊϸʵ»Ͼ绰ʱܳ˵
󣩡ʵ»Ҫ»شԼҪĸԳɼȵȡ
Ȼǡ˵ҪӦǾܵػشʵɡȻڶ
ʵ»ɣǸʷҵı󿼲Ҫԭ򣩱̸ܶ
ɲ꣬ȴ˲ٵƪԺĿĺڣ޷֤
»ڡѧƷϴ⣬ӶóҪѧǡһ
ȷľһ۶ϡʣʶڳ򲻹µõĸԽֱӵ
̭ɣ绰Ҫ»ش⡢ĸԳɼк
ס֮ҵǮ˳ǹȥ󻹸кβס
һоáһҡ޲װɡ

ªо

䡶˵СζضԸ˵ҪŬѧ
˵ںڶʮڶ϶ʵѧߣһѧҡ
һ´˶ۻʲôΪܹ˶Ըʵġ
Ըһ˺ʧѹڶѶڸڷѧ
ǰ;ʾĵǡǣڽܡ¾Ĳɷʱʱ
ѧȷӭʵ»Ĳʿ˻ζż
ʹʵѧõߣҲӭҰڳһɣʵ»
ȷʧܡҲˣھΪʵѧ
Ϊʧܺ󽫡ҵı󿼲ڡ˿һȷʧ
ܡٻӭʼĲʿ˵⣬ص˶֪ˡ
һоáʹڵʦǣڵ
һǷ񹹳˶Ըʵ»ַϵĻ˸ϵġ

ªоҲ塱

䡶˵ԼܼߵĲɷжᵽҹʿ
ƶȵȱԼĸ﷽⣬ԴΪΥ򲢾
ոʵ»ʿһɡܳΪ𣿲ʿ¼ȡеĸͨ
֪ӦоԺѧԺ´ģӺζȻӦо
ԺѧԺݳԳɼԼʿ˵ȷо
취涨ʿ˽ӺζӦɵʦݶԷϸ
޳ɿԸݿеĿп˺ṩȻ
һоԺͷѧԺӦ֪ĸʵ»ȴûеõ֪ͨΪʲô
ҲűԱԴĽͣΪæ𣿣
ϷбΨһĽӦǵʦڣԸʵ»ûн
ʿ˻ΪҪʿˣΪԭͲҪʡʣ
ʵ»ûеõ֪ͨҲƶȵȱȻ
ԼΥֱӵ˴ĲȻȴƶȵȱ
ɱƶǱ󶨵ģҹƶǹҶġ
ΪڸԼĴˮ򱱴ңн
ߡһоԱĲңԹҵĲ塣

¼ǰʵ»򱱴زɲõһ
Ĵ𸴡ȻڶԼĲеͶŵʱѡ
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ѡڡҵı󿼲ҲǶ͹۳޶
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ӣĹڴ˵ԭ

ڡȷӭʵ»ĲʿǷ
ȷʵ»λһҡҲ塱ѧ
ʦ緶νġѧҡ

2004731

(XYS20040801)

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ժҪ  ߾ǰʵ»ǳƵĹھԼĿǰչ
Ϊʵ»ԼƾѣҪĿǰӦ
ԴΪıķչ


ʵ»󿼲ҲȸпʱȻѾȥʮ꣬ڿ
Ϊȴδ仯٣ǲɵдԼƵľ

1995꣬Ҳʵ»ͬܺߡֻͬǣ
ѧʿоҵʱ人ĳҽѧԺУѧӦҵУ
˶ʿоѡѧڼ䣬ҵĳɼһǰéѧУԺϵѧ
ɲѧǳɫΪԼʽѧʱֻ
һоѧұҺͱԶеһ
ɸѡʱͶƱһΪʦһ仰һи
ѡˡʱҲûʲôԼɣô˻Ը
ϰǰѧרҵ֪ʶҸϰ1995Ԫ²μͳһ
ԡ³ԽԸƳɼڱרҵоһλӰףӢ
 56 һ5060רҵһ 87רҵζ 
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ԼϲĿйˡ˺ר־ͶԼıҵĹҲû
ȥұҵĹȥ

νвơµ׵һ죬ںʡҽѧҵоͼΪ
ҵĹ꼸һCA ѧժصѧУյ
¥ǰϵĳλʦ㱻֪人ҩϵҪˣȥԡ
Һܲ죬ΪѾͨоѧԣұĵʦѾң
ҵıԳɼԼڶڼıֺ͸ʦۣѾ¼ȡˡ
Ҿ˵Ҳȥ˰ɣҾˣðͬѧȥɡºұ֪
μӸѾ˺ܴı䶯ϵﵱ¼ȡоλӢ
ֻʮδͨһߣֱܷҵ3040֡һ
ֵܷڶߡֵܷڶߣҲ޿ɺǣ˼ұϾƶߣҲ
ǸûиʸġңУڼ95
ȺʡѧɲƺţԼıҵٻ95Ⱥʡѧ
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ںڿȴڱУԵʸûõȡ֮ұת
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֮λ޴ʡϵоĻĺڰ밹࣬
ĵĻڸǵˣҲĻè彻׵Ʒˡ

Ϊһûκβ۵ŮӣҵʱҪˣÿ
ϴ档ҿʱҵ̸ʦలο֧֣
շתȥ˱˶ʿоȻؼǵ̸ʦο
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ʱͻûʲôˡʧ֪Ǹ粻ƽ̫
ˡȷȥʡίȥ淢£ĽתʹӮ
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ǳڣںӰĿйҵӢһ
ѿ佱ΪYour English is pretty good.ʱںλ
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ҵȷͬʵ»һڲƶȵܺߡǣ
ԿһλھǱˡҾǽܻᷢġĿǰ
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ΪϵڴΨһɲĵĵطԴʵ»
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(XYS20040801)

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ҲƶȲ۸ʵ»Ӧ¼ȡ



زھʹƶȲ棬ֲָʿ
ŷʽʽΪʽʵ»ϵëŷʽ
첩Ȩ˵оͲСβУǴӴԶУ˵
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ԼӾ˽һɵˣͬ첩һ
ŷʽСҪԼĺѡı׼ǲ첩
ĺѡ֪ģУѧϤʶôˣУĸԺ
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ȷġû˵ڵĵʦʦϰˣʹ˻ϰ𣿿
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ҲҪϧģȨΪʱ¢Ļͨճ飬
ðͳߵĹ£Խ߾ҪԿͷ㡣ִᣬ
һͨҲܰ·ôڿǻʱı
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նԱѧԺ¼ۣΪʲôýûȤĻ
ڻϳ죿ԭ򣬾ڴýҪģ
ȫʵ˵ڻϣƾһԺ˶ԵIDʺžͿ
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ԼĽšڣֻʹڸĺô˭
ԷԼƽȵģҲΪ䶷ԵķӡҪ
ǣۣȿֽýҪѵöࡣԺ
ԣ͸óãҲȥѧʲô塱̫ˡ

20040731

(XYS20040801)

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ڸ¡ƹ֪ʶѾĽ죬йһЩԾ
Ӣҽһ־Ӣڵٶɴ˶/
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ȨΪǵѧڵĴˡ֪ʶһҪԴ
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ξӢþӢΪһ塣ҡˡΪֽ˹ϵ
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֪ʶӢݵĽɫʲôϣǷ׷壿ߣֻ
ǰ׷Ϊһ̬Ϊһֱ㣬ΪһԼĻ
ֶΣ֪ʶӢΪԼǾӢͿԶػõϵ
Ȩǡǡ෴һĹ֪ʶҲӦðԼڵ
֮УԼķʡ֮Сƣһʡʹ죬
Ȼǲʱԡǿϸعһι¶棬
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©ԽǺԽûϵҷ˼ԽԽͣԼ
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һĿȻ顣֪ʶӦվʲôϽҲһ
顣£̸ʲô壬ֻǰʧתһֳɹ
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飬ҿͦÇN˳֡ͬѧǿҵĵǴ
뵳飨һ˵Ǵˮҧ
Ĺһ˵Ӧñ־裬ҪƤǻм䡣
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ΪӢҪڣǺڡ־Ӣ
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20ӣǶ˸ǻ֮



¼У۱һǣڸԳÿһڶ෴
˵ƺѱ档һʵ˫ͬϿɵģӦ
ĸֻ˵ʱʼڸѴ꣬ڶѿʼش𣬼
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ʵ˭Ҳ޷ϣΪǿȷ֤ġ

ʵԹ̵㣬ڸеľ壬Ϊ
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ңԭֻԼף޷ԡǣʲôԭ
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ABCҪֻһˣθԾЧġ

֮Ļ⸴ԳɼЧ⣬˵
ӶԭⲢӰԳɼȷ

Ӧһ仰λ֮
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ҲмĿܡǽ֤ʵĿռ䡣Ȼ
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Ϊʲôȶģһԭ򣬾֤ƽȡ
ʵĳж֤ΪÿһȨͿأ
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ܴڵĵͼأΪʲôȫɥʧ龰任
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ΥΥʵ塣ԸΣìܣɱ
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Դȥһֻһֿܣδˡԣɥʧ˸ɥ
ʧǻ֮䣬ԸΪѡɥʧǻۡ

Ҫл¼е20ӣʹǿһΥ˳壬ʹ
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ѾGOOGLEιٴˣûǴȥһβʹ
йȺ֮ʹõGOOGLEȴΪһм
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ȡQQ2003II棬Program Files\Tencent\QQGame\COMToolKit.dll
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(XYS20040801)

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